Advances in Fetal and Neonatal Physiology: Proceedings of by Lubo Zhang, Charles A. Ducsay

By Lubo Zhang, Charles A. Ducsay

To have a good time the heart for Perinatal Biology’s fortieth Anniversary, an illustrious crew collected at Loma Linda college in February 2013. That collecting of specialists and this quantity of the complaints are a tribute to the founding father of the heart, Lawrence D. Longo, M.D. those chapters current contributions from people who indirectly or one other have been inspired via Dr. Longo. protecting quite a lot of subject matters, and illustrating the variety of considering and clinical pursuits, those lawsuits handle uncomplicated technology via to medical difficulties within the developmental programming of future health and illness.

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Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium

To have a good time the guts for Perinatal Biology’s fortieth Anniversary, an illustrious team collected at Loma Linda college in February 2013. That amassing of specialists and this quantity of the complaints are a tribute to the founding father of the guts, Lawrence D. Longo, M. D. those chapters current contributions from people who ultimately or one other have been stimulated through Dr.

Extra resources for Advances in Fetal and Neonatal Physiology: Proceedings of the Center for Perinatal Biology 40th Anniversary Symposium

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Boeldt, Amanda C. Hankes, Roxanne E. Alvarez, Nauman Khurshid, Michael Balistreri, Mary A. Grummer, FuXian Yi, and Ian M. Bird Abstract We have previously reported that the increase in vasodilator production in an ovine model pregnancy is underpinned by an increase in connexin 43 (Cx43) gap junction function, so allowing more uterine artery endothelial cells to produce a more sustained Ca2+ burst response to agonist stimulation. Since activation of endothelial nitric oxide synthase (eNOS) requires elevated [Ca2+]i, it follows that the direct result of enhanced bursting in turn is an increase in nitric oxide (NO) production per cell from more cells, and for a longer period of time.

Effects of long-term, high-altitude hypoxemia on ovine fetal cardiac output and blood flow distribution. Am J Obstet Gynecol. 1993;169:701–7. 14. Gilbert RD, Pearce WJ, Longo LD. Fetal cardiac and cerebrovascular acclimatization responses to high altitude, long-term hypoxia. High Alt Med Biol. 2003;4:203–13. 15. Longo LD, Pearce WJ. Fetal cerebrovascular acclimatization responses to high-altitude, long-term hypoxia: a model for prenatal programming of adult disease? Am J Physiol Regul Integr Comp Physiol.

Very recently, Thomas and co-workers [70] discovered that nitric oxide plays an important role in epigenetics by inhibiting the activity of the demethylase KDM3A through forming a nitrosyliron complex in the catalytic pocket. The authors suggested three distinct mechanisms whereby (•) NO can affect histone methylation as follows: direct inhibition of Jumonji C demethylase activity, reduction in iron cofactor availability, and regulation of expression of methyl-modifying enzymes. Our un-published observations indicate that sGCβ1 expression is epigenetically regulated.

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