Advances in Immunopharmacology. Proceedings of the First by J. Hadden, L. Chedid, P. Mullen

By J. Hadden, L. Chedid, P. Mullen

Advances in Immunopharmacology files the court cases of the 1st foreign convention on Immunopharmacology held in Brighton, England, in July 1980. the quantity comprises 60 papers geared up into 10 components. The papers partly I research the pharmacology of immunotherapeutic medicinal drugs and immunotoxicology. half II provides reviews on thymic hormones. half III is dedicated to immunopharmacologic techniques to illnesses except melanoma. half IV offers with mechanisms of chemotaxis degranulation and microbicidal motion. half V specializes in melanoma immunopharmacology and immunotherapy whereas half VI covers the mechanisms of inflammatory and allergic procedures. half VII takes up the immune trying out of the activities of immunotherapeutic brokers. half VIII discusses prostaglandins and macrophage suppression. half IX is dedicated to chose issues akin to mechanism of motion of soluble immune reaction suppressor and new ways to the treatment of allergic illnesses. half X provides discussions in the course of the treatment conversation classes.

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Additional info for Advances in Immunopharmacology. Proceedings of the First International Conference on Immunopharmacology, July 1980, Brighton, England

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T u r k , J . L . , and D . P a r k e r ( 1 9 7 9 ) . J . , 1 , 1 2 7 - 1 3 7 . W a l k e n s t e i n , S . S . , J . W . D u b b , W . C . R a n d o l p h , W . J . W e s t l a k e , R . M . S t o t e and A . P . I n t o c c i a ( 1 9 7 8 ) . G a s t r o e n t e r o l . , 7 4 , 360-365. Assessment of Immunotoxicity Induced by the Environmental Chemicals 2,3,7,8Tetrachlorodibenzo-p-dioxin, Diethylstilbestrol and Benzo(a)pyrene J. H. DEAN, M. I. LUSTER, G. A. BOORMAN, K. CHAE, L. D. LAUER, R. W.

A slight decrease in body weight gain occurred at the 5 ug/kg TCDD dosage group, but not the 1 ug/kg group, where normal liver weights and serum chemistries were found. These data substantiate previous reports of selective thymus atrophy following TCDD exposure. Recently, CarlstedtDuke (1979) reported the presence of a receptor for TCDD in thymus tissue and liver which was recently confirmed by Chae of this laboratory and reported here. The presence of this receptor may explain the selective toxicity of TCDD for thymocytes, Assessment of Immunotoxicity 47 although the exact location of this receptor still awaits definition.

Reticuloend. Soc. (in press). , Lawson, W. and Robinson, R. (1938) Oestrogenic activity of certain synthetic compounds. Nature, 141, 247. I. G. (1980) Effects on immunocompetence by chemicals of environmental concern. In: E. Hodgson, J. M. ), Reviews in Biochemical Toxicology. Elsevier, New York (in press). , Coats, D. and Graham, N. (1964) Carcinogenic dose response curve to oral diethylstilbestrol. J. Nat. Cancer Inst. , Brown, J. and Okey, A. (1974) Carcinogenic effects of oral diethyl­ stilbestrol on C3H male mice with and without mammary tumor virus.

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